COMPUTER BASED TEXTURAL EVALUATION OF CONCENTRATED GROWTH FACTORS (CGF) IN OSSEOINTEGRATION OF ORAL IMPLANTS IN DENTAL PANORAMIC RADIOGRAPHY

Francesco Inchingolo1,4 Panagiotis G. Georgakopoulos1,2,4 • Gianna Dipalma1,4 Stavros Tsantis3 • Tiziano Batani4 • Ezio Cheno1,4 Ioannis P. Georgakopoulos1,4
1. Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Italy 2. University Alfonso X El Sabio, Dental School, Madrid – Spain 3. Technological Education Institution of Athens, Department of Biomedical Engineering, Athens – Greece 4. World Academy of Growth Factors & Stem Cells in Dentistry

Abstract

Background: Concentrated growth factors (CGF) have positive impact in the field of regenerative medicine. The osseointegration properties of CGF around loaded oral implants were evaluated in this study by means of computerized textural analysis in Panoramic Radiographs. Materials and Methods: Nineteen patients are randomly assigned to two groups. Test group comprise patients that received CGF application within osteotomy site and around new implants. Control group comprise patients with no CGF employment. The region under textural evaluation was the area between the implants in contact with the bone area. A clinical sample of 38 Digitized Panoramic Radiographs was analyzed, 19 corresponding to immediate implant loading and 19 after an 8-month follow-up period. The contact area was derived by means of a complicated segmentation algorithm. From each acquired region from implant windings, 42 textural features were extracted so as to capture the textural differentiation between radiographs that correspond to immediate and after 8 months loading. Results: All selected features achieved Area- Under-Curve (AUC) values within 0.77–0.81 range in the group with CGF employment and manage to capture the significant temporal textural differentiation that can be attributed to CGF properties. The control group, exhibit poor AUC values within 0.51–0.68 range, which in turn shows low osseointegration activity in the bone-to-implant contact area. Conclusion: The positive results of CGF employment have significant clinical interest proving the increment of osteoregenerative potential of surrounding tissues after dental implanting. Quantified evidence derived from the present study can orient the daily surgical procedure towards CGF employment.

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